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Updated: Feb 4, 2026

Liquid-cell Transmission Electron Microscopy for Tracking Self-assembly of Nanoparticles
Published on: October 16, 2017
Fluorescence properties of curcumin-loaded nanoparticles for cell tracking
Bassam Felipe Mogharbel1, Julio Cesar Francisco1, Ana Carolina Irioda1
1Cell Therapy and Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, Curitiba, Paraná, Brazil, katherinecarv@gmail.com.
Background:
Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems.
Materials And Methods:
In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done.
Results:
Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking.
Conclusion:
This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.
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