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Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease
Ming-Chun Chen1, Ji-Hung Wang2,3, Chung-Jen Lee4
1Department of Pediatrics.
Insights
Elevated serum leptin levels predict future cardiovascular events in patients with coronary artery disease (CAD). This finding suggests leptin can be a valuable biomarker for cardiovascular risk assessment in this population.
Area of Science:
- Cardiology
- Endocrinology
- Biomarker Research
Background:
- Hyperleptinemia is linked to cardiovascular (CV) diseases.
- Understanding leptin's role in coronary artery disease (CAD) is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between serum leptin levels and future CV events in patients diagnosed with CAD.
Main Methods:
- A cohort of 98 CAD patients was monitored from 2012 to 2017.
- The study tracked major adverse CV events and hospitalizations as primary endpoints.
- Serum leptin levels were measured and analyzed in relation to CV outcomes.
Main Results:
- Patients experiencing CV events had significantly higher serum leptin levels, systolic blood pressure, total cholesterol, and C-reactive protein.
- Kaplan-Meier analysis revealed a higher cumulative incidence of CV events in patients with elevated leptin.
- Multivariate analysis identified serum leptin levels and triglycerides as independent predictors of future CV events.
Conclusions:
- Serum leptin levels are a significant independent predictor of future cardiovascular events in patients with coronary artery disease.
- Leptin may serve as a potential biomarker for identifying high-risk individuals within the CAD population.
Purpose:
Hyperleptinemia has been independently associated with human cardiovascular (CV) diseases. Accordingly, we evaluate the association between serum leptin and future CV events in patients with coronary artery disease (CAD).
Patients And Methods:
This study enrolled 98 patients with CAD from January to December 2012. The primary endpoint included incidences of major adverse CV events and hospitalization. Patients follow-up had been completed on June 30, 2017.
Results:
After a median follow-up of 52 months, 43 CV events had occurred. Patients with CV events had higher systolic blood pressure (P = 0.030), total cholesterol (P = 0.034), C-reactive protein (P = 0.018), and serum leptin levels (P = 0.001) than those without CV events. Kaplan-Meier analysis showed greater cumulative incidences of CV events in the high leptin group (median leptin concentration >6.03 ng/mL) than in the low leptin group (log-rank P = 0.012). Multivariate Cox regression analysis showed that triglyceride (HR: 1.010; 95% CI: 1.001-1.018; P = 0.022) and leptin levels (HR: 1.054; 95% CI: 1.026-1.082; P < 0.001) were independently associated with CV events in patients with CAD.
Conclusion:
Serum leptin levels could serve as a biomarker for future CV events in patients with CAD.
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