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Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine

Dilyara Nurkhametova1,2, Igor Kudryavtsev3,4, Olga Khayrutdinova5

  • 1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

Frontiers in Cellular Neuroscience
|October 16, 2018
PubMed

Insights

Migraine patients exhibit altered T-cell profiles, particularly regulatory T-cells (Tregs), with reduced expression of CD39 and CD73. This suggests impaired immune regulation, potentially promoting inflammation in migraine.

Area of Science:

  • Immunology
  • Neuroscience
  • Cell Biology

Background:

  • Immune responses are implicated in migraine pathogenesis but remain poorly understood.
  • Purinergic signaling via ATP and adenosine plays a role in immune regulation.

Purpose of the Study:

  • To characterize the purinergic profiles of T-cells in episodic migraine without aura (MWoA).
  • To investigate the involvement of ATP and adenosine in immune regulation within migraine pathophysiology.

Main Methods:

  • Peripheral blood samples analyzed from 16 migraine patients and 21 controls.
  • T-cell subsets identified using flow cytometry and specific membrane markers.
  • Expression of CD39 and CD73 on regulatory T-cells (Tregs) assessed.

Main Results:

  • Migraine patients displayed reduced total T-cell counts.
  • While overall Treg numbers were unchanged, specific Treg subsets (CD45R0+CD62L- and CD45R0-CD62L-) increased.
  • Fewer Tregs in migraine patients expressed CD39 and CD73, indicating disrupted ATP breakdown to adenosine.
  • Negative correlations found between migraine duration and specific Treg populations expressing CD73 and CD39.

Conclusions:

  • T-cell populations are altered in episodic migraine.
  • Regulatory T-cells (Tregs) are implicated in migraine pathophysiology.
  • Reduced CD39 and CD73 expression on Tregs may promote pro-inflammatory ATP signaling and reduce anti-inflammatory adenosine signaling in migraine.
Keywords:
ATPadenosinemigrainepurinergic signalingregulatory T cells

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