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Updated: Feb 3, 2026

Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
Published on: December 22, 2020
A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and
Jinlan Dong1, Wenjing Ning1, Daniel J Mans1
1Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, MO, 63110, USA.
Abstract:
A mixture of α-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (~250-550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.
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