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Updated: Feb 3, 2026

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
Highly sensitive and specific noninvasive in-vivo alcohol detection using wavelength-modulated differential
Xinxin Guo1, Khashayar Shojaei-Asanjan1, Di Zhang1
1Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON M5S 3G8, Canada.
Abstract:
This paper reports the application of wavelength modulated differential photothermal radiometry (WM-DPTR) to blood alcohol (ethanol) concentration (BAC) measurements in the mid-infrared range to prevent impaired driving. In-vivo alcohol consumption measurements performed in the BAC range of interest (0-80 mg/dl) with an optimal wavelength pair demonstrated the alcohol detection capability of WM-DPTR with high resolution (~5 mg/dl) and a low detection limit (~10 mg/dl). Oral glucose tolerance tests using both glucose and alcohol sensitive wavelength pairs in the normal-to-hyperglycemia range (~80-320 mg/dl) proved the blood glucose screening ability and ethanol detection specificity of WM-DPTR. The immunity of WM-DPTR to temperature and glucose variation makes the differential signals alcohol sensitive and specific, yielding precise and accurate noninvasive alcohol measurements in the interstitial fluid.
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