Related Experiment Video
Updated: Feb 3, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
Siyang Liu1, Michael R E Lamont2, Jeffrey A Mulligan1
1School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.
Abstract:
Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After accumulating 12 astigmatism-diverse OCT volumes, we show a 10 dB enhancement in signal-to-background ratio via a coherent average of reconstructed signals from a USAF target located 7.2 scattering mean free paths below a thick scattering layer, and a 3× speckle contrast reduction from an incoherent average of reconstructed signals inside the scattering layer. This AD-OCT method, when implemented using astigmatic illumination, is a promising approach for ultra-deep volumetric optical coherence microscopy.
Related Concept Videos
Diversity of Archaea I
Cell Diversity
Multicellular...
Diversity of Archaea II
Diversity of Protists I
Diversity of Protists II
Scatter Plot

