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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
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Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b
Hershel Patel1, Lauren J Jeang1, Ankit Shah2
1Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Ocular Oncology and Pathology
|October 16, 2018
Summary
Topical interferon alpha-2b effectively treats widespread ocular surface squamous neoplasia involving the entire limbus. Careful staging and biopsies are crucial to exclude invasive disease before treatment.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Ocular surface squamous neoplasia (OSSN) requires precise management.
- Staging is critical for treatment selection.
Purpose of the Study:
- To highlight the significance of staging OSSN.
- To evaluate topical interferon alpha-2b for extensive OSSN.
Main Methods:
- Case study of two patients with 360-degree limbal involvement.
- Treatment with topical interferon alpha-2b.
- Diagnostic confirmation via thorough examination and biopsies to rule out invasive disease.
Main Results:
- Complete response observed in both patients with conjunctival squamous cell carcinoma.
- Topical interferon alpha-2b demonstrated efficacy in widespread intraepithelial OSSN.
- Biopsies successfully excluded invasive squamous cell carcinoma.
Conclusions:
- Widespread intraepithelial OSSN involving the entire limbus is treatable with topical therapies.
- Topical interferon alpha-2b is a well-tolerated first-line agent.
- Long-term monitoring is essential due to unknown recurrence risks.
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