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Updated: Feb 3, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b
Hershel Patel1, Lauren J Jeang1, Ankit Shah2
1Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Purpose:
To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone.
Cases:
Two patients with 360 degrees of limbal involvement.
Results:
Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy.
Conclusion:
Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.
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