Related Experiment Video

Updated: Feb 3, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.7K

Müllerian inhibiting substance/anti-Müllerian hormone as a fertility preservation agent

David Pépin1,2, Mary E Sabatini3, Patricia K Donahoe1,2

  • 1Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston.

Current Opinion in Endocrinology, Diabetes, and Obesity
|October 16, 2018
PubMed
Abstract

Insights

Müllerian inhibiting substance (MIS) shows promise as an ovarian fertoprotectant, protecting against chemotherapy and enhancing cryopreservation. Further research is needed to optimize its use in fertility preservation strategies.

Area of Science:

  • Reproductive Endocrinology
  • Oncofertility
  • Cellular Biology

Background:

  • Oncofertility is an emerging field focused on preserving fertility in cancer patients.
  • Müllerian inhibiting substance (MIS) is gaining attention for its potential role in ovarian protection.

Purpose of the Study:

  • To review the potential of MIS as an ovarian fertoprotectant.
  • To explore MIS mechanisms in protecting against chemotherapy and enhancing cryopreservation.
  • To examine limitations in recombinant MIS pharmacology.

Main Methods:

  • Literature review of experimental treatments and mechanisms of MIS.
  • Analysis of MIS action on granulosa cells and primordial follicles.
  • Evaluation of MIS potential in chemotherapy-induced gonadotoxicity and ovarian tissue cryopreservation.

Main Results:

  • MIS acts directly on granulosa cells of primordial follicles.
  • MIS is a benign reproductive hormone with minimal side effects.
  • Potential applications include protection from chemotherapy and enhanced ovarian tissue cryopreservation.

Conclusions:

  • The efficacy of MIS as a fertoprotectant may vary depending on the chemotherapeutic agent.
  • Further research is required to optimize MIS delivery and integration with current fertility management strategies.

More Related Videos

Fertility Preservation in Patients with Severe Ovarian Dysfunction12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

5.0K
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.6K

Related Concept Videos

Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.1K
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.1K
Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.6K
Plant Hormones01:56

Plant Hormones

Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.6K
Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
91.3K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K