Related Experiment Video
Updated: Feb 3, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
Published on: September 8, 2021
Fast and Easy-to-Perform BRAF Testing in Melanoma Samples: An Accessible Tool for Pathologists With no Experience in
Fanny Barel1, Arnaud Uguen1,2
1Department of Pathology, CHRU Brest, Brest.
Abstract:
BRAFV600 mutation testing is mandatory for treatment choices in patients with advanced melanomas. Besides molecular methods, VE-1 immunohistochemistry has paved the way for BRAF mutation detection by every pathologist, but it only detects BRAFV600E mutant protein, and additional DNA-based molecular analyses are often delegated to molecular genetics laboratories to detect mutations other than BRAFV600E. In this technical article, we present a new diagnostic device that is easy to implement in surgical pathology laboratories, even for pathologists lacking any experience in molecular analyses, to diagnose most of the BRAF mutations encountered in melanoma. The implementation of this fast (<2 h per analysis) and fully automated new real-time polymerase chain reaction diagnostic device, in pathology laboratories, could help to reduce the turnaround times for molecular results, to allow rapid subsequent therapeutic choices in patients with advanced melanomas and other cancers.
Related Concept Videos
Gene Evolution - Fast or Slow?
In contrast, regions which code...
What is an Experiment?
Molecular Models
Fast Fourier Transform
The computational efficiency of the FFT becomes...
The Stanford Prison Experiment
Molecular Orbital Theory II

