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Updated: Feb 3, 2026

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
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Pituitary Adenoma Apoplexy of the Orbit, Diagnosis, and Management With Presurgical Embolization
Nickisa M Hodgson1, Ashley A Campbell1, Jessica R Chang1
1Johns Hopkins University School of Medicine, Wilmer Eye Institute, Baltimore, Maryland, U.S.A.
Abstract:
Orbital invasion of pituitary adenomas has been previously reported. In this report, the authors describe a 71-year-old female with a prolactinoma that presented with invasion of and apoplexy within the orbit. The patient underwent exenteration, followed by rapid tumor recurrence and growth. Given the hemorrhagic nature of the tumor, she subsequently underwent preoperative embolization and surgical resection. This case is notable in that it illustrates both apoplexy of a pituitary tumor within the orbit and the benefit of presurgical embolization.
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