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Updated: Feb 3, 2026

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The role of IL-3 in bone

Niroshani Surangika Soysa1, Neil Alles2

  • 1Division of Pharmacology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Journal of Cellular Biochemistry
|October 16, 2018
PubMed

In the recent past, there has been a burgeoning interest in targeting cytokines such as IL-3 for specific disease conditions of bone such as rheumatoid arthritis and multiple myeloma. Unlike other cytokines, IL-3 is a cytokine with a multilineage potential and broad spectrum of target cells and it plays a vital role in hematopoiesis. Due to its common receptor subunit, the action of IL-3 shows functional redundancy with other cytokines such as the granulocyte-macrophage colony-stimulating factor and IL-5. IL-3 has been successfully used in ameliorating radiation-induced bone marrow aplasia and similar conditions. However, the role of IL-3 in bone cells has not been fully unraveled yet; therefore, the aim of this overview is to present the effects of IL-3 in bone with a special emphasis on osteoclasts and osteoblasts in a concise manner.

Keywords:
IL-3osteoblastosteoclast

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