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Updated: Feb 3, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

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Dimethyl fumarate and teriflunomide for multiple sclerosis in a real-life setting: a French retrospective cohort

S Condé1, X Moisset1,2, B Pereira3

  • 1Service de Neurologie, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.

European Journal of Neurology
|October 16, 2018
PubMed
Abstract

Insights

Dimethyl fumarate (DMF) shows better efficacy in reducing relapsing-remitting multiple sclerosis (MS) relapses over two years compared to teriflunomide. However, teriflunomide offers better treatment tolerance with lower discontinuation rates.

Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Dimethyl fumarate (DMF) and teriflunomide are oral disease-modifying treatments for relapsing-remitting multiple sclerosis (MS).
  • While Phase 3 trials established their efficacy and tolerability, comparative real-world data on effectiveness and discontinuation rates remain limited.

Purpose of the Study:

  • To assess and compare the real-world efficacy and discontinuation rates of DMF and teriflunomide in patients with relapsing-remitting MS.

Main Methods:

  • A retrospective observational cohort study conducted in a French region from March 2014 to July 2017.
  • Compared 189 DMF-treated patients and 157 teriflunomide-treated patients using multivariate analysis, adjusting for factors like MS duration, baseline relapse rate, and disability score.

Main Results:

  • After adjusting for confounders, DMF significantly reduced the annualized relapse rate over two years compared to teriflunomide (0.06 vs. 0.21, P=0.03).
  • DMF-treated patients experienced more clinical and biological adverse events, leading to higher discontinuation rates (28% vs. 12%, P=0.03).

Conclusions:

  • Dimethyl fumarate (DMF) demonstrates superior efficacy in reducing MS relapses over two years compared to teriflunomide.
  • Teriflunomide exhibits better treatment tolerance, resulting in lower discontinuation rates in a real-world setting.
Keywords:
cohort studydimethyl fumarateefficacymultiple sclerosisreal lifesafetyteriflunomidetreatment outcome

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