Related Experiment Video
Updated: Feb 3, 2026

Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
Published on: January 16, 2017
Structural Insight into H-NOX Gas Sensing and Cognate Signaling Protein Regulation
Yirui Guo1, Michael A Marletta1,2,3
1California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, 94720, USA.
Abstract:
Heme-nitric oxide/oxygen binding (H-NOX) proteins are a family of gas-binding hemoproteins that bind diatomic gas ligands such as nitric oxide (NO) and oxygen (O2 ). In bacteria, H-NOXs are often associated with signaling partners, including histidine kinases (HKs), diguanylate cyclases (DGCs) or methyl-accepting chemotaxis proteins (MCPs), either as a stand-alone protein or as a domain of a larger polypeptide. H-NOXs regulate the activity of cognate signaling proteins through ligand-induced conformational changes in the H-NOX domain and protein/protein interactions between the H-NOX and the cognate signaling partner. This review summarizes recent progress toward deciphering the molecular mechanism of bacterial H-NOX activation and the subsequent regulation of H-NOX-associated cognate sensor proteins from a structural and biochemical point of view.
More Related Videos
Related Concept Videos
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Regulated Protein Degradation
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
Gene Regulation in Microbial Communities: Quorum Sensing

