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Updated: Feb 3, 2026
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Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
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[Positron emission tomography : from classical indications to new and future applications]
S Goldman1, E El Darazi1, C Mathey1
1Service de Médecine nucléaire et Unité TEP/Cyclotron biomédical, Hôpital Erasme, ULB.
Revue Medicale De Bruxelles
|October 16, 2018
Summary
Positron emission tomography (PET) with fluorodeoxyglucose (FDG) is essential for cancer diagnosis and increasingly used in neurology and inflammatory conditions. New tracers are expanding PET
Area of Science:
- Nuclear Medicine
- Oncology
- Neurology
Background:
- Positron emission tomography (PET) initially focused on neurology and cardiology but gained prominence in oncology.
- Fluorodeoxyglucose (FDG) became a universal tracer for oncological PET, driving its widespread adoption.
- The extensive use of FDG-PET has led to the emergence of non-oncological applications.
Purpose of the Study:
- To review the evolution and expanding applications of PET imaging.
- To highlight the role of FDG-PET in oncology, neurology, and inflammatory diseases.
- To discuss the impact of novel tracers in broadening PET's clinical utility.
Main Methods:
- Review of clinical applications of PET, focusing on FDG-PET.
- Discussion of established and emerging PET tracers.
- Analysis of PET's role in diagnosis, follow-up, and therapeutic guidance.
Main Results:
- FDG-PET is a cornerstone in cancer diagnosis and management.
- FDG-PET has supplanted gallium-67 in evaluating inflammatory conditions.
- FDG-PET is crucial for diagnosing neurological disorders like epilepsy and dementia, especially with new amyloid/tau tracers.
- Amino-acid tracers and novel agents for neuroendocrine and prostate cancers are expanding oncological PET applications.
Conclusions:
- PET imaging, particularly FDG-PET, has evolved from an oncological tool to a versatile diagnostic method across multiple medical fields.
- Advancements in PET tracers continue to enhance diagnostic accuracy and therapeutic strategies in both oncology and neurology.
- PET imaging holds significant promise for future clinical applications, driven by ongoing innovation in radiotracer development.
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