Related Experiment Video

Updated: Feb 3, 2026

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

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Adipokines in Multiple Sclerosis Patients with and without Optic Neuritis as the First Clinical Presentation

Berna Düzel1, Yusuf Tamam1, Arzu Çoban2

  • 1a Department of Neurology, Faculty of Medicine , Dicle University , Diyarbakır , Turkey.

Immunological Investigations
|October 16, 2018
PubMed
Abstract

Insights

Multiple sclerosis (MS) patients with optic neuritis (ON) as the initial symptom exhibit milder disease and lower adipokine levels. This suggests adipocytokine production is linked to MS progression, warranting further investigation into the underlying mechanisms.

Area of Science:

  • Immunology
  • Neurology
  • Endocrinology

Background:

  • Adipocytokines are implicated in multiple sclerosis (MS) pathogenesis.
  • MS patients experiencing optic neuritis (ON) first often show a milder disease course.
  • This study investigates the link between reduced adipokine production and milder MS progression.

Purpose of the Study:

  • To determine if a milder MS disease course, particularly in patients with ON as the first clinical episode, is associated with reduced adipokine production.
  • To compare adipokine levels in relapsing-remitting MS (RRMS) patients and healthy controls.
  • To explore the relationship between specific adipokines and disease severity in MS.

Main Methods:

  • Serum samples were collected from 55 RRMS patients (24 with initial ON) and 40 healthy controls.
  • Adipokine concentrations (adiponectin, leptin, resistin, MCP-1, IL-8) were quantified using ELISA.
  • Expanded Disability Status Scale (EDSS) scores were assessed in MS patients.

Main Results:

  • RRMS patients exhibited significantly higher levels of adiponectin, leptin, resistin, MCP-1, and IL-8 compared to healthy controls.
  • MS patients whose first episode was ON had lower EDSS scores.
  • Serum levels of adiponectin, leptin, resistin, and MCP-1 were significantly lower in MS patients with initial ON.

Conclusions:

  • MS patients presenting initially with ON demonstrate both reduced disability and lower serum adipokine levels.
  • These findings imply a significant association between adipocytokine production and MS progression.
  • Further research is needed to elucidate the precise mechanisms linking adipocytokines to MS in patients with initial ON.
Keywords:
Adipokinedisabilityfirst clinical episodemultiple sclerosisoptic neuritis

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