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Updated: Feb 3, 2026

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
Identification of key genes in Ankylosing spondylitis
Zhong-Yang Xu1, Chao Zhou2, Ke-Feng Zhang3
1Department of Orthopaedics, Jining NO.1 People's Hospital, China; Department of Orthopaedics, Sandong University Qilu Hospital, China.
Abstract:
Ankylosing spondylitis (AS) is a common form of seronegative spondyloarthritis. We had identified differentially expressed genes (DEGs) in AS based on our previous RNA-sequencing results. Our study aimed to identify key genes in AS by integrated microarray analysis. In this present study, we identified 1328 DEGs between AS and normal control by using integrated analysis of two datasets derived from the Gene Expression Omnibus (GEO) database. Functional annotation of DEGs were performed. Pathways in cancer, Pancreatic cancer and Natural killer cell mediated cytotoxicity were significantly enriched pathways for DEGs. Based on the shared DEGs of AS in both integrated analysis and our previous RNA-sequencing results, we constructed the protein and protein interaction (PPI) network. BIRC2, MAPILC3A and MAGED1 were hub proteins. Validation of gene expression by qRT-PCR were performed and the results were consistent with our integrated analysis generally. Our finding provided new clues for understanding the mechanism of AS.
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