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On the structure-function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular

Jacques Thibodeau1, Mohamed Abdelwafi Moulefera1, Renaud Balthazard1

  • 1Laboratoire d'Immunologie Moléculaire, Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Canada.

Human Immunology
|October 16, 2018
PubMed

Insights

Human Leukocyte Antigen (HLA) class II molecules

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Classical human leukocyte antigen (HLA) class II molecules are polymorphic transmembrane proteins crucial for immune response.
  • While extracellular domains bind microbial peptides, intracellular domains show significant structural divergence.
  • The functional implications of these intracellular variations are not fully understood.

Purpose of the Study:

  • To investigate the role of MHC class II cytoplasmic tails in intracellular trafficking.
  • To explore the interaction between MHC class II cytoplasmic domains and invariant chain (CD74) isoforms.
  • To examine the significance of a conserved lysine residue in beta-chain trafficking.

Main Methods:

  • Focus on the interplay between MHC class II cytoplasmic domains and CD74.
  • Analysis of ubiquitin-driven trafficking influenced by the beta-chain lysine residue.

Main Results:

  • The study highlights the importance of intracellular domains in MHC class II trafficking.
  • Interactions with CD74 isoforms and the conserved lysine residue are key regulatory points.
  • Sequence variations in cytoplasmic tails and transmembrane domains can impact MHC class II function.

Conclusions:

  • MHC class II cytoplasmic tails play a critical role in regulating intracellular trafficking.
  • Understanding these interactions is vital for comprehending immune response variations.
  • Sequence diversity in intracellular domains may contribute to differential immune system functions.
Keywords:
Antigen presentationCD74Di-arginineEndoplasmic reticulumIip35Invariant chainMARCH1MHC class II moleculesPolymorphismUbiquitin

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