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Related Concept Videos

Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
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Lewis Acids and Bases02:16

Lewis Acids and Bases

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This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
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Ions as Acids and Bases02:54

Ions as Acids and Bases

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Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
26.4K
Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

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An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
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Bronsted-Lowry Acids and Bases02:58

Bronsted-Lowry Acids and Bases

105.0K
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
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Acid-Base Titration Curves02:23

Acid-Base Titration Curves

141.2K
A titration curve is a plot of some solution property versus the amount of added titrant. For acid-base titrations, solution pH is a useful property to monitor because it varies predictably with the solution composition and, therefore, may be used to monitor the titration’s progress and detect its endpoint. Acid-base titration can be performed with a strong acid and a strong base, a strong acid and a weak base, or a strong base and a weak acid.
For a titration carried out for 25.00 mL of...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Modified hyaluronic acid based materials for biomedical applications.

Sanjay Tiwari1, Pratap Bahadur2

  • 1Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.

International Journal of Biological Macromolecules
|October 16, 2018
PubMed
Summary

Hyaluronic acid (HA) is a versatile biomaterial with unique properties for biomedical applications. This review highlights HA modifications and their use in targeted drug delivery and biomaterials.

Keywords:
BiocompatibilityBiomaterialsDrug targetingHyaluronic acidHydrophobic modificationSelf-assembly

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Hyaluronic acid (HA) is a high molecular weight polysaccharide with significant biomedical potential.
  • Its biocompatibility, non-toxicity, and non-immunogenicity make it ideal for various applications.
  • HA interacts with CD44 receptors, often overexpressed on tumor cells, enabling targeted delivery.

Purpose of the Study:

  • To review recent advancements in hyaluronic acid modification techniques.
  • To explore the diverse applications of modified HA in biomedical fields.
  • To highlight HA's role in developing targeted drug vectors and implantable biomaterials.

Main Methods:

  • Review of recent literature on HA modifications.
  • Analysis of covalent and non-covalent interaction-based transformations of HA.
  • Examination of HA's use in nanoparticle stabilization and layer-by-layer adsorption.

Main Results:

  • Various chemical modifications enhance HA's properties for specific applications.
  • Modified HA facilitates the creation of self-assembled aggregates, nanoparticles, and gels.
  • HA-based systems show promise for targeted drug delivery and advanced biomaterials.

Conclusions:

  • Hyaluronic acid modifications offer a powerful strategy for developing advanced biomedical materials.
  • HA's versatility supports applications ranging from drug delivery to tissue engineering.
  • Further research into HA modifications will drive innovation in targeted therapies and regenerative medicine.