Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

10.7K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
10.7K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

821
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
821
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

9.1K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
9.1K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

861
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
861
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.3K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Democratized single-cell proteomics resolves cell state heterogeneity in skin tumors.

Life science alliance·2026
Same author

Roles of PknB and CslA in Cell Wall Morphogenesis of Streptomyces.

Molecular microbiology·2026
Same author

Global identification of Chromobacterium violaceum T6SS effectors reveals an Rhs antibacterial toxin featuring FIX and ADP-ribosyltransferase domains.

The Journal of biological chemistry·2026
Same author

Effects of Intraoperative Prone Versus Supine Positioning on Postoperative Delirium.

Geriatrics (Basel, Switzerland)·2026
Same author

Targeting noncanonical nuclear factor kappa B signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha.

The British journal of dermatology·2026
Same author

Optimising the induction of inflammation within preterm infant-derived intestinal epithelial organoids.

Npj gut and liver·2026
Same journal

Chronic Osteomyelitis - Pathophysiology and Treatment.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Posterior Malleolus Fractures of the Tibia: Open Reduction and Buttress Plating versus Percutaneous Fixation with an Anteroposterior Screw.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Ultrasound Assessment of Talar, Femoral and Metacarpal Cartilage Thicknesses in Hemiplegic Patients and their Relationship with Functional Parameters.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Current Concepts in Acute and Chronic Lateral Ankle Instability.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.6K

Heterotopic Ossification - Complication or Chance?

Philip Peter Roessler1, Rahel Bornemann1, Cornelius Jacobs1

  • 1Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn.

Zeitschrift Fur Orthopadie Und Unfallchirurgie
|October 16, 2018
PubMed
Summary
This summary is machine-generated.

Heterotopic ossification (HO) development lacks clear pathophysiological understanding. Future research should explore anti-inflammatory strategies targeting chronic inflammation to improve muscle repair and prevent HO.

More Related Videos

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes
07:12

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Published on: April 21, 2023

3.4K
Heterotopic Heart Transplantation in Mice
23:43

Heterotopic Heart Transplantation in Mice

Published on: July 19, 2007

30.3K

Related Experiment Videos

Last Updated: Feb 3, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.6K
Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes
07:12

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Published on: April 21, 2023

3.4K
Heterotopic Heart Transplantation in Mice
23:43

Heterotopic Heart Transplantation in Mice

Published on: July 19, 2007

30.3K

Area of Science:

  • Trauma and regenerative medicine
  • Inflammation and tissue repair

Background:

  • Pathophysiology of heterotopic ossification (HO) remains unclear.
  • Limited experimental data on post-traumatic inflammatory response and muscle repair.
  • Predisposing factors include hypoxia, VEGF, and BMP.

Purpose of the Study:

  • To investigate the pathophysiological mechanisms of HO development.
  • To explore the balance between muscle regeneration and HO formation.
  • To identify potential targets for early clinical intervention.

Main Methods:

  • Review of existing literature on HO.
  • Analysis of inflammatory response in post-traumatic settings.
  • Exploration of predisposing factors like hypoxia and growth factors.

Main Results:

  • Chronic inflammation is a key pathomechanism in HO.
  • Current prophylaxis with NSAIDs has limitations in efficacy and side effects.
  • Early intervention is suggested for better outcomes.

Conclusions:

  • Further research is needed to elucidate HO pathophysiology.
  • Focus on the interplay between inflammation, muscle regeneration, and HO.
  • Investigating immunosuppressive strategies may offer novel therapeutic avenues.