Related Experiment Video
Updated: Feb 3, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
Functional treatment for acute ankle sprains: Softcast wrap versus MOK-cast. A prospective randomized single-center
J K G Louwerens1, D T Mensch2, O J W Verhoof3
1Department of Orthopaedic Surgery, Spaarnegasthuis Hospital, Spaarnepoort 1, P.O. Box 770, 2134 TM Hoofddorp, The Netherlands.
Background:
The outcome of a removable (MOK-cast) versus a non-removable polyester wrap for acute lateral ankle ligament injury is unknown.
Methods:
Patients with grade II-III lateral ankle ligament injuries were randomized between treatment with a MOK-cast and a wrap. Primary outcome is the Karlsson score for function. Secondary outcomes are patient satisfaction and pain at 4 months follow-up.
Results:
Randomisation resulted in 53 and 54 patients per arm. Four month follow up was completed by 92% (n=100). The mean Karlsson score improved from 20 to 87 (p<0.01) in the wrap group and 20 to 90 (p<0.01) in the MOK-cast group. In the MOK-cast group treatment satisfaction was higher (8.2 vs 7.8 p 0.04). Reported pain was higher in the first thirty days after injury (p<0.01).
Conclusions:
Both wrap and MOK-cast are effective functional treatment options in acute lateral ankle ligament injury. MOK-cast is associated with increased patient satisfaction but higher VAS pain scores.
Level Of Evidence:
I.
More Related Videos
Related Concept Videos
Ankle Joint
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
Clinical Trials: Overview
Trial and Error and Algorithm
Clinical Trials
There are four phases in a clinical trial. A phase one...
Random Error

