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Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake.

Carmen Pineda1,2, Rafael Rios3,4, Ana I Raya5,6

  • 1Department Medicina y Cirugia Animal, University of Cordoba, 14071 Cordoba, Spain. v32pimac@uco.es.

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|October 17, 2018
PubMed
Summary
This summary is machine-generated.

Dietary phosphorus (P) and caloric restriction significantly impact fibroblast growth factor 21 (FGF21) levels in rats. While P intake affects FGF21 in both normal and high-calorie diets, caloric restriction strongly influences FGF21 and β-klotho regulation.

Keywords:
caloriesfibroblast growth factor 21phosphorusrat

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Metabolic Research

Background:

  • The fibroblast growth factor 21 (FGF21)/β-klotho axis plays a crucial role in metabolic regulation.
  • Understanding the interplay between dietary minerals like phosphorus (P) and caloric intake is vital for metabolic health.

Purpose of the Study:

  • To investigate the effects of varying dietary phosphorus levels and caloric intake on the FGF21/β-klotho axis in rats.
  • To elucidate how P intake differentially affects FGF21 under conditions of caloric restriction versus repletion.

Main Methods:

  • Rats were fed diets with normal or high phosphorus (P) and normal, high, or low calories (LC) for up to 7 months.
  • Plasma FGF21 concentrations, liver FGF21 mRNA/GAPDH, and liver β-klotho mRNA/GAPDH and protein/α-tubulin ratios were measured.

Main Results:

  • Plasma FGF21 was higher in normal and high-calorie groups compared to low-calorie groups.
  • Increased P intake decreased FGF21 in normal and high-calorie diets but not in low-calorie diets.
  • Liver β-klotho expression (mRNA and protein) was significantly reduced by caloric restriction, independent of P intake.

Conclusions:

  • β-klotho is primarily regulated by caloric restriction, whereas FGF21 is influenced by both caloric restriction and P intake.
  • High P intake exhibits a differential impact on FGF21 levels depending on the caloric status of the rats.