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Related Concept Videos

Anatomical Movements00:51

Anatomical Movements

15.7K
Anatomical movements refer to the various actions or motions that can be performed by the body's joints and muscles. These movements are described using specific terms to provide a standardized way of discussing and understanding the range of motion at different joints.
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...
15.7K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.5K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.5K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

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In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.4K
Fluid Movement Between Compartments01:18

Fluid Movement Between Compartments

4.0K
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
4.0K
Movement Joints in Buildings01:27

Movement Joints in Buildings

348
Movement joints in buildings are essential design elements that accommodate inevitable motions caused by various factors such as temperature changes, moisture content variations, and structural deflections. These motions, if not considered in design and construction, can lead to unsightly or dangerous damage. Movement joints are incorporated in different forms to manage these stresses and allow materials to move without causing distress.
The simplest type of movement joints, working joints, are...
348
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.6K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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PET Imaging in Movement Disorders.

Baijayanta Maiti1, Joel S Perlmutter2

  • 1Department of Neurology, Washington University in St. Louis, St Louis, MO.

Seminars in Nuclear Medicine
|October 17, 2018
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) offers crucial insights into Parkinson disease pathophysiology. This molecular imaging technique aids in early detection, tracking disease progression, and understanding nonmotor symptoms for better treatment strategies.

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Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Parkinson disease is a neurodegenerative disorder with motor and nonmotor deficits.
  • Early detection and understanding disease progression are critical for effective management.

Purpose of the Study:

  • To review how Positron Emission Tomography (PET) investigations illuminate Parkinson disease pathophysiology.
  • To explore PET's role in identifying presymptomatic individuals and its potential as a biomarker for disease progression.

Main Methods:

  • PET imaging techniques including measurements of regional cerebral glucose metabolism, blood flow, receptors, neurotransmitter systems, and protein deposition.
  • Review of methodologies applied to Parkinson disease clinical issues.

Main Results:

  • PET reveals changes in the brain that may precede Parkinson disease onset.
  • PET can serve as a biomarker for disease progression and aid in enriching clinical study cohorts.

Conclusions:

  • PET imaging is vital for understanding Parkinson disease pathophysiology, from early changes to nonmotor symptoms.
  • Molecular imaging with PET supports early diagnosis, personalized treatment strategies, and clinical trial advancements.