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Astrocytes in the mouse visual cortex reliably respond to visual stimulation.

Keita Sonoda1, Teppei Matsui2, Haruhiko Bito3

  • 1Department of Physiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Molecular Physiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Biochemical and Biophysical Research Communications
|October 17, 2018
PubMed
Summary

Astrocytes in mouse visual cortex respond to visual stimuli, but with a delay of several seconds compared to neurons. This suggests a shared neuron-astrocyte communication mechanism across species.

Keywords:
AstrocyteIn vivo two-photon Ca(2+) imagingMouseNeuronPrazosinVisual cortex

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Astrocytes, glial cells in the brain, interact with synapses and may process sensory information.
  • While ferret astrocytes show delayed visual responses, mouse astrocyte responses remain unclear.

Purpose of the Study:

  • To investigate astrocyte visual responses and their timing relative to neurons in the awake mouse visual cortex.
  • To determine if astrocytes in mice exhibit delayed visual responses similar to ferrets.

Main Methods:

  • Utilized dual-color in vivo two-photon calcium imaging to simultaneously observe neurons and astrocytes.
  • Administered prazosin, an alpha1-adrenergic receptor antagonist, to differentiate visual from neuromodulator-mediated astrocytic activity.

Main Results:

  • Neurons responded reliably to visual stimuli; astrocytes exhibited global activities that masked visual responses.
  • Prazosin reduced global astrocytic activity, revealing weak but consistent astrocytic visual responses, primarily in somata.
  • Astrocytic visual responses were delayed by approximately 5 seconds relative to neuronal responses.

Conclusions:

  • Astrocytes in the mouse primary visual cortex respond to visual stimuli with a significant delay compared to neurons.
  • This delayed response suggests a conserved mechanism for neuron-astrocyte communication across different species.