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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Gene Flow02:39

Gene Flow

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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Gene Conversion02:08

Gene Conversion

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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Related Experiment Video

Updated: Feb 3, 2026

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
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Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

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Cochlear Gene Therapy.

Lawrence Lustig1, Omar Akil2

  • 1Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York Presbyterian Hospital, New York, New York 10032.

Cold Spring Harbor Perspectives in Medicine
|October 17, 2018
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Summary
This summary is machine-generated.

Gene therapy offers new hope for hearing loss, a condition affecting millions globally. Recent advances focus on cochlear gene therapy, exploring delivery methods and target genes to restore hearing.

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Area of Science:

  • Otolaryngology
  • Genetics
  • Molecular Biology

Background:

  • Hearing loss impacts over 450 million people worldwide, posing a significant economic burden.
  • Recent scientific progress has elucidated the molecular basis of hearing and identified genetic/environmental factors contributing to hearing loss.

Purpose of the Study:

  • To review the latest advancements in cochlear gene therapy for hearing restoration.
  • To discuss viral vectors, construct designs, inner ear delivery methods, and promising therapeutic genes.

Main Methods:

  • Literature review of recent research in cochlear gene therapy.
  • Analysis of viral vector technologies and gene construct designs.
  • Evaluation of inner ear delivery strategies and gene targets.

Main Results:

  • Significant progress has been made in developing gene therapy for hearing loss.
  • Various viral vectors and delivery methods are being explored for inner ear application.
  • Identification of key genes holds promise for therapeutic interventions.

Conclusions:

  • Cochlear gene therapy is a rapidly advancing field with the potential to treat hearing loss.
  • Further research into optimized vectors, delivery, and gene targets is crucial for clinical success.