Related Experiment Video
Updated: Feb 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interstitial lung disease and inflammatory myopathy in antisynthetase syndrome with PL-12 antibody
Ameen Jubber1, Mudita Tripathi1, James Taylor1
1Rheumatology, Northampton General Hospital NHS Trust, Northampton, UK.
Abstract:
We report the case of an 80-year-old Caucasian man with PL-12 antibody positive antisynthetase syndrome. He presented with progressive dyspnoea and weight loss, later developing dysphagia, mild proximal muscle weakness and mild sicca symptoms. Investigations revealed interstitial lung disease, inflammatory myopathy and an immunology profile consistent with PL-12 antisynthetase syndrome. Prednisolone and cyclophosphamide resulted in a significant improvement of all his symptoms.
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