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Related Concept Videos

Angular Momentum: Single Particle01:10

Angular Momentum: Single Particle

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Angular momentum is directed perpendicular to the plane of the rotation, and its magnitude depends on the choice of the origin. The perpendicular vector joining the linear momentum vector of an object to the origin is called the “lever arm.” If the lever arm and linear momentum are collinear, then the magnitude of the angular momentum is zero. Therefore, in this case, the object rotates about the origin such that it lies on the rim of the circumference defined by the lever arm...
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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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Principle of Linear Impulse and Momentum for a Single Particle01:20

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Linear momentum is a fundamental concept in physics that describes the motion of an object. It is a vector quantity, having a magnitude equal to the product of its mass and its velocity, and direction along the object's velocity. On the other hand, linear impulse, also known as momentum impulse, is a concept in physics related to the change in the linear momentum of an object. Impulse is a vector quantity defined as the product of force and the time over which the force is applied.
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Electron Microscope Tomography and Single-particle Reconstruction01:07

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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Consider a wooden box and a cylinder of known masses m1 and m2, respectively,  hanging from a ceiling with the help of a massless pulley system.
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Subatomic Particles03:37

Subatomic Particles

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Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
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A Microfluidic-based Hydrodynamic Trap for Single Particles
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Single Particle Automated Raman Trapping Analysis.

Jelle Penders1,2,3, Isaac J Pence1,2,3, Conor C Horgan1,2,3

  • 1Department of Materials, Imperial College London, London, SW7 2AZ, UK.

Nature Communications
|October 17, 2018
PubMed
Summary
This summary is machine-generated.

A new platform, Single Particle Automated Raman Trapping Analysis (SPARTA), enables high-throughput analysis of individual nanoparticles. This technology offers detailed insights into nanoparticle size, composition, and surface dynamics for diverse scientific applications.

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Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Materials Science

Background:

  • High-throughput analysis of single nanoparticles is crucial for understanding variations in size and composition.
  • Existing bulk analysis methods face limitations in sensitivity and specificity for complex nanoparticle systems.

Purpose of the Study:

  • To develop a comprehensive platform for the integral, high-throughput analysis of single nanoparticles.
  • To enable label-free characterization of diverse nanoparticle types without modification.

Main Methods:

  • Development of a controlled automated trapping process for single nanoparticle manipulation.
  • Utilizing Raman spectroscopy for sensitive, high-throughput analysis of individual particles.

Main Results:

  • The Single Particle Automated Raman Trapping Analysis (SPARTA) platform successfully analyzes various nanoparticles, including synthetic polymers and liposomes.
  • High-throughput analysis resolves particle mixtures, provides detailed compositional spectra, tracks functionalizations, determines particle size, and monitors surface reaction dynamics.

Conclusions:

  • The SPARTA platform overcomes limitations of bulk analysis, offering label-free, integral, high-throughput single particle characterization.
  • This technology opens new research avenues in polymer science, drug delivery, and other fields requiring detailed nanoparticle analysis.