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Related Experiment Videos

Deafferentation elicits a transient decrease in Na+, K+-ATPase activity and ouabain binding in the olfactory

A C Swann, Z Gottesfeld

    Brain Research
    |February 24, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Olfactory bulbectomy temporarily reduces Na+, K+-ATPase activity and ouabain binding in the olfactory tubercle. These changes coincide with dopaminergic sprouting, returning to normal levels by 42 days post-lesion.

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • The olfactory tubercle is a key brain region involved in processing olfactory information.
    • Na+, K+-ATPase is a crucial enzyme for maintaining neuronal membrane potential and function.
    • Olfactory bulbectomy is a surgical procedure used to study the effects of olfactory system damage.

    Purpose of the Study:

    • To investigate the impact of olfactory bulbectomy on Na+, K+-ATPase activity and ouabain binding in the olfactory tubercle.
    • To determine the temporal profile of these changes and their relationship with dopaminergic activity.

    Main Methods:

    • Olfactory bulbectomy was performed on experimental subjects.
    • Na+, K+-ATPase activity was measured biochemically.
    • Ouabain binding assays were used to quantify enzyme sites.

    Related Experiment Videos

  • Enzyme activity and binding were assessed at 14, 21, and 42 days post-lesion.
  • Corpus striatum and hippocampus served as control regions.

    • Main Results:

    • A significant reduction in Na+, K+-ATPase activity and ouabain binding was observed in the olfactory tubercle at 14 and 21 days after bulbectomy.
    • No significant changes were found in the corpus striatum or hippocampus.
    • Enzyme activity and binding returned to normal levels by 42 days post-lesion.
    • The observed reduction in Na+, K+-ATPase activity coincided temporally with previously reported dopaminergic sprouting and increased dopamine-sensitive adenylate cyclase activity.

    Conclusions:

    • Olfactory bulbectomy induces a transient decrease in Na+, K+-ATPase activity and ouabain binding in the olfactory tubercle.
    • These neurochemical alterations are linked to the adaptive responses of the dopaminergic system following olfactory system damage.
    • The olfactory tubercle exhibits a capacity for recovery of Na+, K+-ATPase function after injury.