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Related Concept Videos

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

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Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Enzymes02:34

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Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
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The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
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Intramural Injection of Botulinum Toxin A in Surgical Treatment of a Long Gap Esophageal Atresia-Rat Model.

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Related Experiment Video

Updated: Feb 3, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Angiotensin-Converting Enzyme Inhibitor-Induced Gastrointestinal Angioedema: The First Danish Case Report.

Marijana Rincic Antulov1, Runar B Båtevik1

  • 1Department of Surgery, Sydvestjysk Sygehus, Esbjerg, Denmark.

Case Reports in Gastroenterology
|October 17, 2018
PubMed
Summary

Angiotensin-converting enzyme inhibitors (ACEI) can rarely cause gastrointestinal angioedema (GA). Discontinuing ACEI therapy is key for rapid symptom resolution and avoiding unnecessary procedures.

Keywords:
Abdominal painAngiotensin-converting enzyme inhibitorsBradykininGastrointestinal angioedema

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Angiotensin-converting enzyme inhibitors (ACEI) are standard treatments for hypertension and heart failure.
  • Angioedema is a rare but serious side effect of ACEI therapy.

Observation:

  • A 45-year-old female experienced sudden, severe abdominal pain.
  • Imaging revealed edematous changes in the small bowel wall.
  • The patient had been taking ACEI for six months.

Findings:

  • ACEI therapy was discontinued, leading to rapid symptom improvement.
  • ACEI-induced gastrointestinal angioedema (GA) lacks specific diagnostic markers.
  • Symptoms of GA typically resolve completely upon cessation of ACEI treatment.

Implications:

  • Early recognition of ACEI-induced GA is crucial.
  • Prompt diagnosis can prevent invasive investigations like laparotomy.
  • Awareness among clinicians can improve patient outcomes and reduce healthcare costs.