Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tryptamine receptors: fact, myth or misunderstanding?

A J Greenshaw, W G Dewhurst

    Brain Research Bulletin
    |February 1, 1987
    PubMed
    Summary

    Specific tryptamine binding sites in the brain may function as receptors, potentially impacting neuropsychiatric illnesses. Research confirms these sites are selective and not due to other enzyme binding.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Methodological approaches to situational analysis in global mental health: a scoping review.

    Global mental health (Cambridge, England)·2019
    Same author

    Aversive stimulus properties of the 5-HT2C receptor agonist WAY 161503 in rats.

    Neuropharmacology·2006
    Same author

    Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats.

    Psychopharmacology·2005
    Same author

    Differential effects of intra-midbrain raphe and systemic 8-OH-DPAT on VTA self-stimulation thresholds in rats.

    Psychopharmacology·2004
    Same author

    The enigma of conditioned taste aversion learning: stimulus properties of 2-phenylethylamine derivatives.

    Physiological research·2002
    Same author

    Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression.

    Molecular psychiatry·2001

    Area of Science:

    • Neuroscience
    • Neurochemistry
    • Pharmacology

    Background:

    • Tryptamine, an endogenous brain amine, is involved in neural regulation.
    • Tryptamine is implicated in the etiology of several neuropsychiatric disorders.
    • Specific tryptamine binding sites have been recently reported in the central nervous system.

    Purpose of the Study:

    • To critically review the current developments regarding specific tryptamine binding sites.
    • To discuss the potential role of these sites as functional tryptamine receptors.
    • To address challenges in specificity and functional assessment of these binding sites.

    Main Methods:

    • Review of existing literature on tryptamine binding sites.
    • Analysis of studies using [3H]-tryptamine for binding site characterization.
    • Evaluation of experiments involving drug treatment and brain lesions (electrolytic, neurotoxin-induced).

    Main Results:

    • The [3H]-tryptamine binding site exhibits selectivity.
    • Binding is not attributable to residual monoamine oxidase binding.
    • Functional assessment of these sites remains an area of active investigation.

    Conclusions:

    • Evidence suggests the existence of specific tryptamine binding sites in the brain.
    • These sites are potential candidates for functional tryptamine receptors.
    • Further research is needed to fully elucidate their role in neuropsychiatric conditions.

    Related Experiment Videos