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Updated: Feb 3, 2026

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
Published on: June 13, 2018
Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
Huensuk Kim1,2,3, Christoph Schaniel1,2,3,4,5
1Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Abstract:
The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review the progress in the field and discuss the advantages, limitations, and challenges of iPSC-based malignancy modeling. We will also discuss the use of iPSCs and its derivatives as cellular sources for drug target identification, drug development and evaluation of pharmacological responses.
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