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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
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Exosome-mediated cell-cell communication in tumor progression
Zhuo Wan1, Xiaotong Gao1, Yan Dong1
1Department of Hematology, Tangdu Hospital, Fourth Military Medical University Xi'an 710038, Shaanxi, China.
American Journal of Cancer Research
|October 17, 2018
Summary
Exosomes are key players in the tumor microenvironment, mediating cancer progression. This review explores their role in angiogenesis, metastasis, and chemo-resistance, offering insights into exosome-based cancer therapies.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Exosomes are nano-sized vesicles crucial to the tumor microenvironment.
- They facilitate intercellular communication by transferring bioactive molecules like lipids, nucleic acids, and proteins.
- Cancer cell-derived exosomes exhibit altered compositions impacting tumor progression.
Purpose of the Study:
- To review recent advances in exosome biogenesis and function in cancer.
- To highlight the role of exosomes in tumor angiogenesis, metastasis, and chemo-resistance.
- To provide perspectives on exosome-based strategies for cancer diagnosis, prevention, and therapy.
Main Methods:
- Literature review of recent studies on cancer exosomes.
- Focus on exosome biogenesis under cancerous conditions.
- Analysis of exosome functions in tumor progression.
Main Results:
- Exosomes are significantly altered in cancer cells and associated stromal cells.
- These modified exosomes play critical roles in promoting tumor angiogenesis and metastasis.
- Exosomes contribute to tumor chemo-resistance, impacting treatment efficacy.
Conclusions:
- Exosomes are integral to the tumor microenvironment and cancer progression.
- Understanding exosome biogenesis and function is vital for cancer research.
- Exosome-based approaches hold promise for novel cancer diagnostics and therapeutics.
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