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Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Enhancing Visual Outcomes in Cataract Surgery: A Novel Technique to Prevent Posterior Capsular Opacification Through IOL Rotation

Author Spotlight: Enhancing Visual Outcomes in Cataract Surgery: A Novel Technique to Prevent Posterior Capsular Opacification Through IOL Rotation

Published on: July 7, 2023

Intraocular Photobonding to Enable Accommodating Intraocular Lens Function.

Nicolas Alejandre-Alba^1,2, Rocio Gutierrez-Contreras², Carlos Dorronsoro²

¹Department Ophthalmology, University Hospital Fundación Jiménez-Díaz, Madrid, Spain.

Translational Vision Science & Technology

|October 17, 2018

Summary

Intraocular photobonding successfully attached a capsular bag to an intraocular lens (IOL) using light. This new technique for accommodating IOLs (A-IOLs) may restore vision in patients with presbyopia.

Keywords:

accommodating intraocular lenses cataract surgery crystalline lens exchange photoactivation photobonding presbyopia

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Area of Science:

Ophthalmology
Biomaterials Science
Surgical Innovation

Background:

Accommodating intraocular lenses (A-IOLs) aim to restore the eye's natural focusing ability.
Current A-IOL designs often rely on capsular bag integrity or fibrosis for function.
A novel approach using photobonding could enhance A-IOL performance.

Purpose of the Study:

To demonstrate the feasibility of intraocular photobonding between a capsular bag and an intraocular lens (IOL).
To evaluate the strength of the photobonded interface under simulated physiological forces.

Main Methods:

Phacoemulsification was performed on porcine eyes.
A poly(2-hydroxyethyl methacrylate) (pHEMA) IOL was inserted into the capsular bag.
The interface was irradiated intraocularly using a diode laser and Rose Bengal photosensitizer.
Bond strength was assessed via uniaxial tensile testing.

Main Results:

Successful photobonding was achieved within specific laser irradiance and irradiation time parameters.
The photobond withstood forces (0.12 N) exceeding the ciliary muscle's accommodative force (0.08 N).
In some cases, the natural zonular attachments failed before the photobond.

Conclusions:

Intraocular photobonding between the capsular bag and IOL is achievable and compatible with cataract surgery.
This technique offers a new mechanism for A-IOLs, independent of capsular bag integrity.
Potential applications include restoring accommodation for presbyopia and other ophthalmic procedures.