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Related Experiment Video

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Shaping a Flap Using a Bioabsorbable Mold-A Preliminary Report.

Akimitsu Nishibayashi1,2, Koichi Tomita1, Mifue Taminato1

  • 1Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Plastic and Reconstructive Surgery. Global Open
|October 17, 2018
PubMed
Summary

A bioabsorbable mold helped control soft-tissue shape in rats, improving projection and base area ratio for potential breast reconstruction applications. Further research is needed for clinical use.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Plastic Surgery

Background:

  • Previous 3D-printed breast molds showed limitations in detailed shape creation.
  • In vivo evaluation of bioabsorbable molds for flap shape retention during scar formation was investigated.

Purpose of the Study:

  • To assess the efficacy of a bioabsorbable mold in controlling flap shape and volume during the scar formation period.
  • To compare outcomes of using a bioabsorbable mold versus traditional sutures for flap shaping in vivo.

Main Methods:

  • Vascularized adipose flaps were created in rats (n=7).
  • A bioabsorbable mold (LactoSorb mesh) was used to shape the flap on one side, with the other side serving as a control (suture shaping).
  • Flap volume, base area, and projection were measured using 3D imaging after 3 months.

Main Results:

  • The mold side showed a trend towards smaller volume and base area, closer to template values.
  • A significantly greater projection-to-base area ratio was observed on the mold side (P=0.04).
  • Histology confirmed minimal inflammation and no significant difference in scar tissue thickness between groups.

Conclusions:

  • Bioabsorbable molds can provide some control over soft-tissue morphology.
  • The findings suggest potential for bioabsorbable molds in surgical applications like breast reconstruction.
  • Further clinical investigation is warranted to validate these results in human patients.