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Published on: November 9, 2016
Movement disorders in emergency settings: a prospective study
Carlo Dallocchio1, Angela Matinella2, Carla Arbasino1
1Department of Medical Area, Neurology Unit, ASST Pavia, Via Volturno, 14, 27058, Voghera, PV, Italy.
Introduction:
Acute movement disorders (MD) are etiologically heterogeneous entities. Since studies on the relative frequency of different MD and their underlying diseases are limited, we performed a prospective study to investigate the spectrum of various MD and their causes in patients presenting with acute MD in an emergency room (ER) setting.
Objective:
To describe the spectrum and outcomes of acute MD in a prospective cohort and to guide its management.
Methods:
We investigated acute MD in 96 consecutive patients admitted to ERs between 2013 and 2017. Time of disease onset, type of MD according to published criteria, diagnostic workup, and outcome were collected.
Results:
73.9% of patients had hyperkinetic MD. Tremor was the most common symptom (19.8%), followed by myoclonus (17.7%), dystonia (15.6%), and chorea (11.4%). Other hyperkinetic MD (9.4%) included were gait disorders (imbalance due to involuntary movement), dyskinesia, akathisia, hemiballism, and oculogyric crisis. Hypokinetic MD included acute parkinsonism (15.6%), off-state (4%), akinesia (3%), and rigidity (3%). Co-occurrence of more than one MD was seen in 19.7% of patients. Time delay to medical consultation was between < 24 h and 28 days. Five etiological groups were recognized: drug-induced (29.2%), functional (19.8%), neurodegenerative diseases (15.6%), structural brain damage (11.5%), others (24.0%, metabolic, inflammatory, infective, undetermined). Outcome was better for neurodegenerative diseases and for drug-induced MD. Functional movement disorders (FMD) showed less favorable outcome.
Conclusions:
Acute MD is a distinct cause of ER admission, and a variety of treatable diseases may be the underlying cause of this symptom. Uncertain course is more probable in FMD and in structural brain lesions.
Insights
Acute movement disorders (MD) are common in emergency rooms, often caused by drugs or functional issues. While some causes have good outcomes, functional movement disorders and structural brain lesions may have uncertain prognoses.
Area of Science:
- Neurology
- Emergency Medicine
Background:
- Acute movement disorders (MD) are etiologically diverse.
- Limited studies exist on the relative frequency and underlying causes of various MDs.
Purpose of the Study:
- To prospectively investigate the spectrum and outcomes of acute MD in emergency room (ER) patients.
- To guide the management of acute MD.
Main Methods:
- A prospective study of 96 consecutive patients presenting with acute MD to ERs between 2013 and 2017.
- Collected data on disease onset, MD type, diagnostic workup, and patient outcomes.
Main Results:
- Hyperkinetic MDs were most common (73.9%), with tremor, myoclonus, dystonia, and chorea as frequent symptoms.
- Key etiological groups included drug-induced (29.2%), functional (19.8%), neurodegenerative diseases (15.6%), and structural brain damage (11.5%).
- Outcomes were better for neurodegenerative and drug-induced MDs, while functional movement disorders (FMD) and structural brain lesions had less favorable prognoses.
Conclusions:
- Acute MD is a significant reason for ER visits, with various treatable underlying causes.
- Functional movement disorders and structural brain lesions are associated with a more uncertain clinical course.
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