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Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?
Claudia Maria Hattinger1, Maria Pia Patrizio1, Elisa Tavanti1
1a Laboratory of Experimental Oncology , IRCCS Istituto Ortopedico Rizzoli , Bologna , Italy.
Expert Review of Molecular Diagnostics
|October 17, 2018
Summary
Advances in genetic testing for osteosarcoma are identifying new biomarkers. These genetic markers aid in predicting treatment toxicity, prognosis, and detecting relapse, paving the way for personalized cancer therapies.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Osteosarcoma genetic characterization has advanced significantly over the last decade.
- Integrated application of conventional, candidate-driven, and genome-wide technologies has driven this progress.
Purpose of the Study:
- To review the current state of genetic testing in osteosarcoma.
- To highlight novel genetic biomarkers for predicting toxicity, prognosis, and relapse.
- To discuss the role of genetic testing in tailoring patient treatment strategies.
Main Methods:
- Review of recent literature on genetic characterization of osteosarcoma.
- Analysis of conventional and advanced genetic testing technologies.
- Focus on candidate genetic biomarkers from tumor tissue and blood samples.
Main Results:
- Emerging genetic biomarkers show potential for predicting treatment toxicity and patient prognosis.
- Genetic markers can aid in early detection of disease relapse.
- Improved patient selection criteria for tailored treatments are being developed.
Conclusions:
- Modern genetic testing is identifying new prognostic markers and driver genes in osteosarcoma.
- These findings may reveal novel therapeutic targets and patient stratification biomarkers.
- Tailored treatment approaches are expected to improve outcomes, especially for metastatic disease.
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