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Updated: Feb 3, 2026

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Making way for suppressing the FGF19/FGFR4 axis in cancer

Nestor Prieto-Dominguez1,2, Austin Y Shull3, Yong Teng1,4

  • 1Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, USA.

Future Medicinal Chemistry
|October 17, 2018
PubMed

Insights

Fibroblast Growth Factor 19 (FGF19) regulates key physiological processes. Inhibiting the FGF19/FGFR4 pathway shows promise for novel cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Fibroblast Growth Factor 19 (FGF19) is a key regulator of bile acid homeostasis, liver metabolism, and glucose uptake.
  • The FGF19/FGFR4/β-klotho receptor complex mediates these physiological responses through intracellular signaling.
  • Overactivation of the FGF19/FGFR4 axis is linked to cancer development, progression, and metastasis.

Purpose of the Study:

  • To review recent advancements in FGF19/FGFR4-targeted therapeutics.
  • To explore the application of these targeted therapies in cancer treatment.

Main Methods:

  • Literature review of recent studies on FGF19/FGFR4 axis.
  • Analysis of therapeutic strategies targeting the FGF19/FGFR4 pathway.
  • Examination of preclinical and clinical data for FGF19/FGFR4 inhibitors.

Main Results:

  • FGF19/FGFR4 axis inhibitors are emerging as potential anticancer agents.
  • These inhibitors are being developed for monotherapy and combination treatments.
  • Targeting the FGF19/FGFR4 complex is a promising strategy in oncology.

Conclusions:

  • The FGF19/FGFR4 axis plays a critical role in cancer.
  • Targeted therapeutics offer a new avenue for cancer treatment.
  • Further research into FGF19/FGFR4 inhibitors is warranted for effective cancer therapy.
Keywords:
FGF19FGFR4anticancerinhibitorsoncogenic rolesignaling transductiontreatment regimens

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