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Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
Published on: January 9, 2019
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Electrically Evoked Auditory Brainstem Response over Round Window by Bipolar Stimulation
Noelia Munoz Fernandez1, Carlos de Paula Vernetta1, Laura Cavelle Garrido1
1Department of ENT, La Fe University and Polytechnic Hospital, Valencia, Spain.
The Journal of International Advanced Otology
|October 17, 2018
Summary
This study introduces a new method for reliable electrically evoked auditory brainstem responses (eEABRs) in cochlear implant (CI) candidates. Bipolar stimulation of the round window (RW) proved more effective than monopolar stimulation for eEABR recordings.
Area of Science:
- Neuroscience
- Audiology
- Biomedical Engineering
Background:
- Auditory brainstem potentials can be elicited by round window (RW) electrical stimulation.
- Extracochlear stimulation is used for cochlear implant (CI) candidate selection to prevent cochlear damage.
- Previous methods were limited by large electrical stimulation artifacts.
Purpose of the Study:
- To develop a reliable and reproducible method for obtaining electrically evoked auditory brainstem responses (eEABRs).
- To overcome limitations of existing extracochlear stimulation techniques.
Main Methods:
- Prospective study of 49 subjects undergoing CI surgery (2013-2016).
- Utilized a 'Stimulator Box' for CI-like electrical stimuli and evoked potential recording equipment.
- Compared monopolar versus bipolar electrode stimulation on the RW.
Main Results:
- Stable RW eEABR recordings with Wave V between 3-5.5 ms were achieved.
- Increasing phase duration yielded more responses than increasing pulse amplitude.
- Bipolar stimulation resulted in a significantly higher percentage of positive responses compared to monopolar stimulation (p<0.001).
Conclusions:
- The described extracochlear electrical stimulation technique enables reliable and reproducible eEABR recordings.
- Bipolar electrical stimulation probes are superior for eEABR assessment in CI candidates.
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