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Related Experiment Video

Updated: Feb 3, 2026

Derivation of a Human Brain Organoid with Microglia Development

Derivation of a Human Brain Organoid with Microglia Development

Published on: January 17, 2025

Human brain development and its in vitro recapitulation.

Yusuke Seto¹, Mototsugu Eiraku¹

¹Laboratory of Developmental Systems, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan.

Neuroscience Research

|October 17, 2018

Summary

This summary is machine-generated.

Understanding human brain development is crucial for cognitive function. This review explores human-specific brain growth features and the use of brain organoids as a model system.

Keywords:

ES/iPS cells Human brain development Neocortex Organoid SFEBq culture

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Area of Science:

Neuroscience
Developmental Biology
Stem Cell Research

Background:

Human intellectual ability relies on proper brain development.
Brain malformations are linked to cognitive dysfunction.
Studying human brain development is challenging due to sample limitations.

Purpose of the Study:

To review human-specific features in brain development.
To discuss brain organoid technology as a model for studying human brain development.
To focus on neocortical development.

Main Methods:

Review of existing literature on mammalian and human brain development.
Analysis of human-specific developmental processes.
Examination of brain organoid technology derived from human pluripotent stem cells.

Main Results:

Mammalian brain development shares common mechanisms like neural stem cell proliferation and neurogenesis.
Humans exhibit unique features in these developmental processes, crucial for brain structure.
Brain organoids partially replicate human fetal brain development, offering a viable model.

Conclusions:

Human brain development has species-specific characteristics vital for cognitive abilities.
Brain organoids provide a valuable tool for investigating human brain development and associated pathologies.
Further research using organoids can elucidate mechanisms of neocortical development.