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The Relationship between Mismatch Negativity and the COMTVal108/158Met Genotype in Schizophrenia

Sho Horikoshi1, Tetsuya Shiga2, Hiroshi Hoshino2

  • 1Department of Psychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan, sho1025@fmu.ac.jp.

Neuropsychobiology
|October 17, 2018
PubMed

Insights

Schizophrenia patients with the COMTVal108/158Met genotype showed differences in mismatch negativity (MMN), an auditory brain response linked to cognitive function. This finding may help understand schizophrenia

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Mismatch negativity (MMN) is an auditory event-related potential reflecting automatic change detection, often deficient in schizophrenia and linked to cognitive decline.
  • The Catechol-o-methyltransferase (COMT) Val108/158Met genotype influences prefrontal dopamine and cognitive function in schizophrenia.
  • The relationship between COMT genotype and MMN in schizophrenia remains uninvestigated.

Purpose of the Study:

  • To investigate the association between the COMT Val108/158Met genotype and MMN characteristics in Japanese schizophrenia patients.

Main Methods:

  • Measured MMN duration, amplitude, and latency in 49 schizophrenia patients.
  • Genotyped the COMT Val108/158Met polymorphism (rs4680) using PCR-RFLP.
  • Compared MMN parameters between Val/Val homozygotes (n=21) and Met carriers (n=28).

Main Results:

  • Significant differences in MMN amplitude and latency were observed between the COMT Val/Val and Met carrier groups.
  • The specific differences in MMN parameters related to the COMT genotype require further elucidation.

Conclusions:

  • The COMT Val108/158Met genotype is associated with MMN alterations in schizophrenia patients.
  • This genetic influence on MMN may contribute to understanding cognitive deficits in schizophrenia.
Keywords:
COMTVal108/158MetCatechol-o-methyltransferaseEvent-related potentialGeneMismatch negativitySchizophrenia

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