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Toxic leukoencephalopathy with extrapyramidal dysfunction due to synthetic cannabinoids.
Jordan Yardain Amar1, Jeffrey Ruta2, David Rahimian2
1Department of Neurology, Washington University School of Medicine, 1 Brookings Road, Campus Box 8121, St. Louis, MO 63110, United States.
Summary
Synthetic cannabinoids can cause serious neurologic sequelae, including movement disorders. This case highlights potential white matter and basal ganglia damage from synthetic cannabinoid use.
Area of Science:
- Neurology
- Toxicology
- Neuroimaging
Background:
- Synthetic cannabinoids (SCs) are recreational drugs with poorly understood toxic effects.
- Neurologic complications of SCs are increasingly reported but remain under-investigated.
Observation:
- A case study of a woman who consumed synthetic cannabinoids.
- The patient presented with hyperreflexia, paratonia, and cogwheel rigidity.
Findings:
- Magnetic Resonance (MR) imaging revealed T2/FLAIR signal abnormalities.
- These signal changes were observed in the supratentorial white matter and globus pallidus internus.
Implications:
- This case suggests SCs can induce specific patterns of central nervous system damage.
- Further research is needed to elucidate the mechanisms and long-term consequences of SC-induced neurotoxicity.
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