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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Studying Wnt Signaling During Patterning of Conducting Airways
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Long non-coding RNAs regulate Wnt signaling during feather regeneration.

Xiang Lin1, QingXiang Gao1, LiYan Zhu1

  • 1Institute of Life Sciences, Fuzhou University, Fuzhou, Fujian, China.

Development (Cambridge, England)
|October 18, 2018
PubMed
Summary

Long non-coding RNAs (lncRNAs) play a role in feather regeneration. Specific lncRNAs (Twnt group) regulate this process by inhibiting Wnt signaling, offering a model for lncRNA functional annotation.

Keywords:
ChickenFeather follicleLncRNARegenerationWnt signaling

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Area of Science:

  • Developmental Biology
  • Genomics
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of diverse biological processes.
  • Feather regeneration provides a model system to study developmental mechanisms.

Purpose of the Study:

  • To investigate the functional roles of lncRNAs in chicken feather regeneration.
  • To identify lncRNAs associated with Wnt signaling during feather development.

Main Methods:

  • RNA-sequencing (RNA-seq) of regenerating feather blastema.
  • Co-expression analysis to identify lncRNAs linked to Wnt pathway genes.
  • Experimental validation of selected lncRNA functions.

Main Results:

  • Wnt signaling is highly active during feather regeneration.
  • Hundreds of lncRNAs were identified, categorized into Lwnt and Twnt groups based on co-expression with Wnt ligands or targets.
  • Twnt group lncRNAs were found to regulate feather regeneration and axis formation, inhibiting Wnt signaling while being downstream targets.

Conclusions:

  • Feather regeneration is a valuable model for systematic lncRNA functional annotation in the chicken genome.
  • Specific lncRNAs (Twnt group) are key regulators of feather regeneration via Wnt pathway modulation.