Related Experiment Video
Updated: Feb 3, 2026

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
Nesfatin-1/Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in
Guang-Ming Liu1, Zi-Qiang Xu1, Hong-Shun Ma1
1Department of Urology in Tianjin First Center Hospital, No. 24, Fukang Road, Nankai District Tianjin 300192, China.
Abstract:
In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bladder cancer using immunohistochemistry and observed that its high expression was associated with recurrence and metastasis. In addition, the transwell assay and wound healing assay showed that cell migration and invasion were decreased with NUCB2 knockdown in T24 and 5637 cells. In vivo, tumor growth and metastasis were inhibited with shRNA treatment in T24 cells. Those results showed that NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor in bladder cancer.
Related Concept Videos
Cancer Cell Migration through Invadopodia
Predicting Products: SN1 vs. SN2
With increased substitution on the alkyl halide,...
Cell Migration
Cell Migration
Cells Coordinate Growth and Proliferation
Abnormal Proliferation

