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Bone Marrow Aspiration Does Not Induce a Measurable Pain Response Compared to Sham Procedure
Aileen L Rowland1, Cristobal Navas de Solis1, Mauricio A Lepiz2
1Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.
Frontiers in Veterinary Science
|October 18, 2018
Summary
Bone marrow aspiration in horses did not show measurable pain responses compared to a sham procedure. This study assessed pain indicators like salivary cortisol and heart rate variability during the process.
Area of Science:
- Veterinary Medicine
- Equine Science
- Regenerative Medicine
Background:
- Bone marrow collection is common in horses for regenerative medicine.
- Limited data exists on the pain experienced by horses during bone marrow aspiration (BMA).
Purpose of the Study:
- To characterize horse reaction and pain response during BMA versus a sham procedure.
- To investigate differences in salivary cortisol, heart rate variability, and sedation depth.
Main Methods:
- A randomized cross-over design with 12 horses undergoing both BMA and sham procedures.
- Sedation with xylazine hydrochloride; assessment of head height, sedation score, salivary cortisol, and heart rate variability.
Main Results:
- No significant differences in head height, sedation score, or salivary cortisol between BMA and sham procedures.
- Heart rate variability showed a decrease in the low frequency/high frequency (LF/HF) ratio after BMA, but not during.
- Both procedures led to a reduction in the LF/HF ratio over time.
Conclusions:
- Sternum BMA in sedated horses did not produce a measurable pain response during or in the 2 hours following the procedure compared to a sham.
- Further research may be needed to fully understand equine pain perception during invasive procedures.
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