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Updated: Feb 3, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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Anti-vascular endothelial growth factor in glioblastoma: a systematic review and meta-analysis

Qiuxiang Xiao1, Shaochun Yang2, Guanfu Ding2

  • 1Department of Pathology, The first Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, Jiangxi, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|October 18, 2018
PubMed

Insights

Anti-vascular endothelial growth factor (anti-VEGF) agents improved progression-free survival (PFS) in glioblastoma patients but did not significantly impact overall survival (OS). Further research is needed to establish their therapeutic role.

Area of Science:

  • Neuro-oncology
  • Clinical trial analysis
  • Cancer therapeutics

Background:

  • Glioblastoma is a common adult primary brain tumor with limited treatment options.
  • Current therapies for glioblastoma often yield unsatisfactory outcomes.
  • Anti-vascular endothelial growth factor (anti-VEGF) agents are being explored to improve patient survival and quality of life.

Purpose of the Study:

  • To evaluate the efficacy of anti-VEGF agents in glioblastoma treatment.
  • To determine the impact of anti-VEGF agents on overall survival (OS) and progression-free survival (PFS).

Main Methods:

  • A systematic search of multiple databases and hand searching was conducted.
  • Ten randomized controlled trials (RCTs) met eligibility criteria; six were included in a meta-analysis.
  • Data were extracted, and a random-effects model meta-analysis was performed using RevMan software.

Main Results:

  • Meta-analysis included 1078 patients in the anti-VEGF group and 946 in the control group.
  • No significant improvement in overall survival (OS) was observed for anti-VEGF agents (OR 0.87, p=0.23) or bevacizumab (OR 0.84, p=0.17).
  • Significant improvement in progression-free survival (PFS) was noted for anti-VEGF agents (OR 0.76, p=0.0007) and bevacizumab (OR 0.75, p=0.0001).

Conclusions:

  • Anti-VEGF agents demonstrate efficacy in improving PFS for glioblastoma patients.
  • These agents do not significantly improve OS in glioblastoma.
  • Current evidence is insufficient to establish anti-VEGF agents as a standard therapy; further high-quality RCTs are required.
Keywords:
Anti-VEGFBevacizumabGlioblastomaMeta-analysisSurvival

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