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Updated: Feb 3, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
Selective drug-free cancer apoptosis by three-dimensional self-targeting magnetic nickel oxide nanomatrix
Sivaprasad C Vijayakumar1,2,3, Krishnan Venkatakrishnan1,2,3,4, Bo Tan3,5
1Ultrashort Laser Nanomanufacturing Facility, Department of Mechanical & Industrial Engineering, Ryerson University, 350 Victoria street, Toronto, Ontario, M5B 2K3, Canada.
Aim:
To develop a drug-free strategy addressing limitations of current cancer therapy.
Materials & Methods:
A 3D self-assembled magnetic nickel oxide (NiO) nanomatrix is synthesized using femtosecond pulsed laser to mimic extracellular matrix.
Results:
The tunable laser pulse-interaction time and repetition rate aided in generating programmable NiO nanomatrix chemistry. The nanomatrix mimicked extracellular matrix in physical configuration and properties presenting favorable cues to cancerous HeLa cell and fibroblast cell adhesion and proliferation without cytotoxicity. The 3D nanomatrix structure altered HeLa cell behavior and induced apoptosis cancer apoptosis with an evidence of increased endocytosis when compared with fibroblast cells.
Conclusion:
The results demonstrate the availability of new potential avenues for magnetic drug-free cancer therapeutics.
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09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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