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Updated: Feb 3, 2026

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
Published on: May 1, 2018
Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
Ivan Pavlinov1, Erica M Gerlach, Leslie N Aldrich
1University of Illinois at Chicago, Department of Chemistry, 845 West Taylor Street, Chicago, IL 60607, USA. aldrich@uic.edu.
Abstract:
Diversity-oriented synthesis has historically focused on the generation of small-molecule collections with considerable scaffold, stereochemical, and appendage diversity. Recently, this focus has begun to shift to the production of small-molecule libraries with diverse biological activities. It is currently not clear which properties and structural features of molecules are predictive of diverse performance in biological assays, and a better understanding of this relationship is critical for the development of performance-diverse small-molecule libraries for the discovery of novel probes for challenging targets. This review explores recent synthetic strategies for the production of bioactive small molecules and concludes with a presentation of current methods that enable the assessment of the biological performance diversity of small-molecule libraries.
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