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Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity

S Ghotloo1, H Motedayyen1,2, D Amani3

  • 1Department of Laboratory Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Journal of Periodontal Research
|October 18, 2018
PubMed
Abstract

Insights

MicroRNA-146a (miR-146a) levels are elevated in generalized aggressive periodontitis (GAgP) and correlate with disease severity. This suggests miR-146a may indicate periodontal disease progression.

Area of Science:

  • Immunology
  • Genetics
  • Periodontology

Background:

  • MicroRNA-146a (miR-146a) regulates innate immunity; its dysregulation is linked to inflammatory conditions.
  • Generalized aggressive periodontitis (GAgP) diagnosis relies on clinical inflammation, age of onset, and family history.

Purpose of the Study:

  • To investigate miR-146a levels in gingival tissues of GAgP patients.
  • To determine the association between miR-146a expression and GAgP severity.

Main Methods:

  • Gingival tissue samples were collected from 18 GAgP patients and 10 healthy controls.
  • Real-time PCR quantified miR-146a and its targets (TNF-α, IL-1β, IL-6).
  • Clinical parameters (probing depth, attachment loss) were measured and correlated with miR-146a levels.

Main Results:

  • miR-146a levels were significantly higher in GAgP patients than in healthy controls (P < .001).
  • Elevated miR-146a expression directly correlated with increased disease severity (P < .05).
  • Increased miR-146a was associated with reduced pro-inflammatory cytokine levels.

Conclusions:

  • A significant association exists between miR-146a and GAgP.
  • miR-146a may serve as a potential biomarker for periodontal disease severity.
  • Further research is needed to elucidate miR-146a's role in periodontitis development and progression.
Keywords:
aggressive periodontitismicroRNA-146apro-inflammatory cytokines

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