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An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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GeneLab: Omics database for spaceflight experiments.

Shayoni Ray1, Samrawit Gebre2, Homer Fogle2

  • 1Space Biosciences Division, USRA/NASA Ames Research Center, Moffett Field, CA, USA.

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|October 18, 2018
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Summary
This summary is machine-generated.

The GeneLab Data System (GLDS) provides open access to curated spaceflight omics data. This database democratizes research by organizing complex datasets and facilitating collaborative analysis for space biology.

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Area of Science:

  • Space biology
  • Bioinformatics
  • Genomics

Background:

  • Spaceflight experiments generate vast amounts of omics data.
  • Organizing and accessing this data is crucial for maximizing scientific return on investment.
  • Democratizing access to this data can accelerate space biology research.

Purpose of the Study:

  • To curate and organize spaceflight experiment data.
  • To provide open access to omics data from space stations.
  • To maximize the scientific return on investment for spaceflight research.

Main Methods:

  • Developed the GeneLab Data System (GLDS) as an open access database.
  • Integrated genomics, transcriptomics, proteomics, and metabolomics data.
  • Implemented federated search across bioinformatics repositories and a collaborative platform.

Main Results:

  • GLDS houses 172 curated datasets with detailed metadata and radiation dosimetry.
  • Supports federated search and full-text querying with assistive filters.
  • Provides a collaborative platform for data sharing and analysis.

Conclusions:

  • GLDS successfully democratizes access to spaceflight omics data.
  • The system enhances the scientific return on investment for spaceflight experiments.
  • Facilitates collaborative research in space biology.