LncBook: a curated knowledgebase of human long non-coding RNAs

Area of Science:

• Molecular Biology
• Genomics
• Bioinformatics

Background:

• Long non-coding RNAs (lncRNAs) play crucial roles in biological processes.
• The rapid increase in identified lncRNAs necessitates better annotation and functional understanding.
• Current knowledge gaps hinder the elucidation of lncRNA molecular mechanisms.

Purpose of the Study:

• To introduce LncBook, a comprehensive, curated knowledgebase for human lncRNAs.
• To facilitate understanding of lncRNA functions and disease associations through data integration.
• To provide a valuable resource for the research community.

Main Methods:

• Systematic curation of human lncRNAs using multi-omics data integration.
• Functional annotation of lncRNAs.
• Association analysis of lncRNAs with diseases.
• Integration of expression, methylation, genome variation, and lncRNA-miRNA interaction data.

Main Results:

• LncBook contains 270,044 lncRNAs, including 1,867 featured lncRNAs with 3,762 function associations.
• It integrates extensive multi-omics data, including expression, methylation, and genome variation.
• The database incorporates 3,772 experimentally validated lncRNA-disease associations and identifies 97,998 putatively disease-associated lncRNAs.

Conclusions:

• LncBook serves as a centralized, curated repository for human lncRNA data.
• The knowledgebase aids in understanding lncRNA functions and their links to diseases.
• LncBook is a valuable resource for advancing lncRNA research globally.