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Updated: Feb 3, 2026
In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
Preoperative Quadriceps Muscle Strength and Functional Ability Predict Performance-Based Outcomes 6 Months After
Niveditha Devasenapathy1, Ralph Maddison2, Rajesh Malhotra3
1Indian Institute of Public Health-Delhi, Public Health Foundation of India, Plot 47, Sec 44, Institutional Area, Gurgaon-122002, Haryana, India; and School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia.
Background:
One-third of individuals report limitations in activities of daily living even 6 months after total knee arthroplasty (TKA). Moderate-quality evidence exists for several sociodemographic and clinical predictors of patient-reported outcome measures of perceived functionality. Objectively measured performance-based measures (PBMs) provide a less subjective approach to informing patient treatment after TKA; however, information about predictors of functionally relevant PBMs is scarce.
Purpose:
This systematic review synthesized the available research on preoperative predictors of PBMs after primary TKA for osteoarthritis.
Data Sources:
In June 2016 and January 2017, MEDLINE, EMBASE, and PsycINFO databases were searched.
Study Selection:
Cohort studies exploring preoperative predictors of stair climbing, walking speed, and gait speed measured ≥6 months after primary TKA were included. Screening of abstracts and selection of full texts were undertaken by 2 independent reviewers.
Data Extraction:
Information on study design, patient characteristics, analysis, and results was extracted using pilot-tested forms. Two independent reviewers assessed risk of bias using modified Quality in Prognostic Studies criteria.
Data Synthesis:
Of the eligible 12 studies involving 6 prospective cohorts, 10 studies reported information on baseline predictors. Meta-analysis of predictors was not possible because of missing information on effect size or standard errors. Narrative synthesis of evidence of predictors was therefore performed.
Limitations:
The quality of evidence was low because of the risk of bias and heterogeneity of included studies as well as nonreporting of measures of effect.
Conclusions:
Low-quality evidence exists for an association of preoperative functional ability and quadriceps muscle strength with functionality at 6 months after TKA. Improved reporting of predictor analyses is needed to enable evidence generation for clinical management.
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